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Oral fucoxanthin (10 mg/kg) reduced experimentally UVB-induced skin pigmentation in guinea pigs, probably due to suppression of proinflammatory cytokine prostaglandin E2 (PGE2) synthesis and receptors involved in melanogenesis [85]
Gammaglutamylcysteine synthetase knock-out mice have been developed for both the heavy and the light subunits [1315]

[DOI] [PMC free article] [PubMed] [Google Scholar] 300
