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This revealed a robust association between high circulating concentrations of TMAO and increased prevalence of diabetes mellitus: people with high circulating concentrations of TMAO were 50% more likely to have diabetes than those with lower levels, and people with diabetes had higher levels of TMAO than nondiabetic people

Because it is a catch-all term that encompasses many different body areas, it can oversimplify the conversation and lead to vague or unclear communication about the specific concerns and desired outcomes for each individual

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Renal impairment, worsening renal function, and outcome in patients with heart failure: an updated meta-analysis