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Dosage and duration of LAC and -lipoic acid (ALA) have shown no antidepressant effect on patients with BD, which also had insignificant enhancement of mitochondrial function in patients (62, 64)

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Precise identification of metabolic subphenotypes enables the selection of interventions that match individual pathophysiology, while chronotherapeutic strategies align treatment delivery with endogenous metabolic rhythms to maximize efficacy and minimize side effects (Table S7)

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