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Arterioscler Thromb 15 : 232240

Specifically, CAR T cells in the day 28 BM of LTR had significantly higher expression of mTOR, pS6, pAKT (mTOR and pAKT pathways) and the metabolic sensor AMPK, as well as significant increases in the fermentative glycolysis enzyme LDHA, the endogenous fatty acid metabolism enzymes SCD1, LAL, and CD45RA, suggesting an effector immunometabolic phenotype

Although most of these studies rely on descriptive or correlation-based analyses, integrative bioinformatic frameworks hold great potential for advancing the field

Geography More common in Africa, Mediterranean, Middle East and South East Asia