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Moreover, nanoparticles must navigate through the brain's extracellular space after traversing the BBB, which constitutes approximately 20% of the brain's total volume and is generally around 20 nm wide
Riboflavin (vitamin B2) and oxidative stress: a review

This is one of the earliest and most destructive events in both TBI and stroke, making Pinealon potentially valuable in the acute phase of brain injury
