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Pregnant and breastfeeding women: The requirement increases to 2.6 mcg per day

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437 In a cohort study on non-frail elderly (mean age 82) men and women with atrial fibrillation in Norway, researchers showed that both standard and low-dose DOACs had a similar risk profile in regard to strokes and clots compared to warfarin, with a similar or decreased risk of bleeding issues

Safety and Pharmacology Evaluations : Conducting preclinical toxicology, pharmacokinetic, and receptor-binding studies to characterize how AOD 9604 is handled in vivo and confirm it does not activate growth hormone-like proliferative pathways