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Proc Natl Acad Sci U S A

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Molecular processes during fat cell development revealed by gene expression profiling and functional annotation

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Overexpression of NNMT has been linked to obesity, insulin resistance, and impaired NAD metabolism

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It also improved the proliferative and secretory functions of fibroblasts and reversed morphological abnormalities of senescent cells (such as flattened cell shape, enlarged volume, and nuclear pyknosis)

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