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Traditional biodosimetry methods, such as dicentric chromosome analysis and lymphocyte micronucleus assays, have a long history of practical use but reveal significant limitations when faced with the highthroughput screening demands of large affected populations [130, 328]
Free thiols are uncommon in modern drug molecules due to their reducing potential, which enables them to form di-sulfide bridges with cysteine residues or self-aggregate
doi: 10.1002/ijc.29071 134 McCulloughMLZoltickESWeinsteinSJFedirkoVWangMCookNRet al
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