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FOXO4-DRI was systemically administrated in both our study and that of the compound designer [24]

Rats receiving the large capsule showed increased glial proliferation, brain swelling, and angiogenesis, while those receiving small doses showed preservation of a large number of tyrosine hydroxylase-positive fibers and a neuroprotective effect on dopamine neurons, indicating that VEGF at low doses can potentially support PD treatment (Yasuhara and Shingo 2005)

Because of this process, there may be a defined period between regulatory eligibility and clinical availability of certain peptide formulations
