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After oral administration, peptides may be decomposed into smaller molecules during gastrointestinal digestion, resulting in the reduction and even loss of their activities (Ketnawa et al., 2018
Formaldehyde-mediated DNA protein crosslinking A probe for in vivo chromatin structures
However, in some cases, PDAC was changed to a biologically more aggressive tumour after depletion of the stroma 14,15,16 , indicating that restoration of the fibrotic stromal homoeostasis maybe a more appealing therapeutic approach 17, 18
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