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However, once cargo length exceeds 3 kb or exhibits high structural rigidity, the system should pivot toward sequence- or structure-guided active recruitment to overcome the entropic penalties of encapsulation and ensure native capsid architecture

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Additionally, damaged mitochondria release mtDNA into the cytosol, activating the innate immune system via damage-associated molecular patterns (DAMPs) (251, 377), modulating both innate and adaptive immune responses (377379)