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10.1164/ajrccm.151.5.7735596 27 DoyleK.LnnH.KckH.Van de PolA.SwallowS.GardinerP.et al (2016)

All of the above results demonstrated that CDCZA nanoparticles combined with the enhanced chemotherapy/CDT could produce the excellent anticancer effect from the molecular perspective, providing a new method for the clinical treatment of esophageal cancer

As noted above, the enzyme -glutamyl cysteine synthetase (Figure 2, reaction 4) is the main rate-limiting step in the -glutamyl cycle and this reaction is nonallosterically inhibited by physiologic concentrations of glutathione (42,43)