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Regulatory approval could still be years away, and long-term safety data beyond 1218 months doesnt yet exist

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Recently, BRD4 was identified as a transcriptional repressor of autophagy and lysosomal biogenesis, independent of TFEB/TFE3/MITF-mediated mechanisms

Whether CuPDTC-induced apoptosis depends on calpain (rather than caspase) needs to be further investigated in a variety of cancer cells
