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11 This observation suggests that either mast cells might not play an essential role in sustaining pNF tumorigenesis or other immune cells in the heterozygous tumour microenvironment compensate for the loss of mast cell function in this specific murine model

In addition, NQO1 overexpression in breast cancer, gastric adenocarcinoma, lung, and uterine cervix carcinoma was markedly associated with increased tumor size, severity of histology of tumors, clinical stage, and lymph node metastasis [4,6,25,26]

Several case studies have reported the onset of mania and rapid-cycling bipolar disorder following cerebellar lesions caused by either surgery or trauma, which indicates a potential role for the cerebellum in the pathophysiology of bipolar disorder [110,111,112]

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