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Intrathecal injection of CSF from AD patients (containing highly expressed let-7b) into the CSF of wild-type mice resulted in neurodegeneration, whereas injection into CSF of mice lacking TLR7 did not result in neurodegeneration, suggesting the pivotal role of microRNAs such as let-7b in TLR7 signaling mediated CNS damage (Lehmann et al., 2012

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Mabagala FS, Geng YH, Cao GJ, Wang LC, Wang M, Zhang ML (2020) Effect of silicon on crop yield, and nitrogen use efficiency applied under straw return treatments