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Overall, there is still a lack of convincing evidence for the clinical efficacy of functional food actives, and large-scale, high-quality RCTs are urgently needed to facilitate the translation of these actives from the laboratory to clinical applications

Braz J Biol 83:e271232

Therefore, an informed, in-depth discussion of its involvement in these pathologic processes is necessary, as a precise contribution of HIF- 1 to CCH-induced VaD remains to be established and requires further investigation

Nanoarchitectured structure and surface biofunctionality of mesoporous silica nanoparticles