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Notably, reduced BDNF levels within the nigrostriatal pathway have been documented in both patients with PD and animal models of the disorder

Moreover, combining these approaches with CRISPR/Cas9 genome editing offers transformative potential for personalized cell replacement therapies by enabling the precise genetic correction of hiPSCs, paving the way for individualized regenerative medicine strategies (189)

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Wishart DS (2015) Is cancer a genetic disease or a metabolic disease