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The simplified comparison is this: Semaglutide: GLP-1 receptor activity Tirzepatide: GIP and GLP-1 receptor activity Retatrutide: GIP, GLP-1, and glucagon receptor activity under clinical investigation More receptor activity does not automatically mean a medication is better for every patient

Thus, the essential significance goes to each of the substances designated to be a neurotransmitter, and thereby, the pleiotropic significance of the acknowledged neurotransmitters such as acetylcholine, histamine, dopamine, glutamine, glycine, GABA, noradrenaline, and adrenaline [12,13,14]

(December 2001)