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Its intracellular depletion ultimately results in cell death, and its clinical relevance has been researched for decades

In addition, proanthocyanidins as polyphenolics showed neuroprotective effects against several neurotoxins (-amyloid25-35, pentylenetetrazole, and rotenone) that caused negatively modulating apoptotic signaling pathways, alleviating oxidative and inflammatory damage [86,87,88,89,90,91,92,93]

doi: 10.1016/j.jphotobiol.2016.07.029 232 IrfanMMunirHIsmailH

PMID: 40541645 Mar Drugs Xanthocillin X Dimethyl Ether Exhibits Anti-Proliferative Effect on Triple-Negative Breast Cancer by Depletion of Mitochondrial Heme