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The result indicates that the overall pathway is feasible but acetate kinase (AckA) is the limiting step (Figure 4)
Therefore, an altered redox state of the ETC induced by inhibiting ETC electron carriers can increase superoxide production, contributing to an imbalance in the cellular redox state, which may cause oxidative stress [102,103]

ESCRT-III-mediated membrane repair in cell death and tumor resistance

Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells
