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After stopping a CYP3A4 inhibitor, as the effects of the inhibitor decline, the hydrocodone plasma concentration will decrease (see CLINICAL PHARMACOLOGY), resulting in decreased opioid efficacy or a withdrawal syndrome in patients who had developed physical dependence to hydrocodone bitartrate and acetaminophen tablets

10.1016/S0969-2126(97)00281-5 70 PreissnerS.KrollK.DunkelM.SengerC.GoldsobelG.KuzmanD.et al

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Their investigation revealed that upregulating GPX3 expression through the use of a GPX3 overexpression plasmid mitigated IR-induced oxidative stress