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Because GH and IGF-1 signaling can influence fluid balance, connective tissue, metabolism, and glucose regulation, potential GH-axis-related effects include: Water retention Peripheral edema Joint stiffness or discomfort Muscle aches Paresthesias or tingling Carpal-tunnel-like symptoms Changes in insulin sensitivity or glucose handling Adult GH replacement literature consistently identifies fluid-retention-related effects including edema, arthralgia, carpal tunnel syndrome, and paresthesias as common side effects of GH treatment

Cd concentrations in human subcutaneous and visceral adipose tissues exhibited a negative correlation with a persons BMI

2001, doi: 10.1054/ghir.2001.0239

The 5-year risk of subsequent hip, spine, and other fractures as well as mortality were ascertained