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In the core, a necrotic nucleus forms due to the prolonged lack of oxygen and nutrients
However, when produced in excess, they can lead to oxidative damage over time, disrupting cellular functions and ultimately causing cell death by harming DNA, RNA, lipids, and proteins (Isik et al
166 , 167 , 168 Therefore, curcumin and P-gp association in myeloma should be examined in future studies
