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Mammalian GLRX contains two cysteines in a C-X-X-C active site motif, allowing for the reduction of protein disulfides and deglutathionylation

Sterol regulatory element-binding proteins (SREBPs), peroxisome proliferator-activated receptor-alpha (PPAR-), AMP-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), nuclear factor erythroid 2-related factor 2 (Nrf2), sirtuins1 (SIRT1), and nuclear factor kappa B (NF-B), fatty acid synthase (FAS), glutathione (GSH), oxidized glutathione (GSSG), 4-hydroxynonenal (4-HNE) and malondialdehyde-acetaldehyde adducts (MAA)

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Molecular mechanism for a gateway drug: epigenetic changes initiated by nicotine prime gene expression by cocaine