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In T cell activation, glutamine deprivation has been shown to alter the activation of naive CD4 + T cells and result in their differentiation into forkhead box P3-positive (Foxp3 + ) regulatory T (T reg ) cells, which have suppressor functions 109

Abnormal tumor vascular systems often affect pH levels and create a hypoxic environment, which in turn affects the efficacy of antineoplastic drugs

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