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For example, human monocytes exposed to purified exogenous HSP70 (7 nM at 37 C for 24 h) increased IL-1, IL-6 and TNF through CD14 engagement and NF-Bmediated signaling (Somensi et al., 2017)

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Our results corroborate a broad base of prior observational studies and smaller-scale reviews which have long noted that children with ASD often exhibit vitamin D deficiency and perturbations in one-carbon metabolism