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To modify antioxidants in therapy, strategies include targeting GPX4 activity, manipulating GSH levels, optimizing exogenous antioxidants, and exploiting Nuclear factor erythroid 2related factor 2 (NRF2) pathways [254]
15 :28-40 doi:10.1007/s10495-009-0408-9 46
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Demonstrated that systemic injections of cartilage-targeted IGF-1 fusion proteins had direct effects on the growth plate without off-target effects on the kidney that are seen with normal IGF-1
