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It is not unlikely that hyperglycemia-stimulated mitochondrial dysfunction and apoptosis account for cardiac metabolic memory [200]

Lipid-based vehicles, including self-emulsifying systems and liposomal constructs, may enhance solubility or promote lymphatic transport

While drug expulsion from SLNs is caused by a reduction of amorphous regions in the lipid matrix due to a polymorphic transition from the less-ordered -form to the more-ordered -form, which reduces the space available for drug molecules, the drug is consequently expelled from the lipid core and may migrate to the particle surface or surrounding medium, leading to a gradual decrease in drug loading efficiency over time (Westesen et al., 1997
