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First, p53 inhibits glycolysis via the repression of glucose transporters (GLUTs) [177,178,179], glycolytic enzymes such as hexokinase 2 (HK2), phosphofructokinase (PFK1), and lactate dehydrogenase A (LDHA) [180,181,182,183], and HIF-1 [184], which may lead to a compensate metabolic shift diverting pyruvate into mitochondria, fueling the TCA cycle

This benefit differentiation makes the grapefruit seed extract vs grape seed extract selection heavily favor grape seed extract for applications requiring evidence-based health benefits, established safety profiles, and reliable therapeutic outcomes

There may be no such thing as dying from old age

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