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In induced pluripotent stem cell (iPSC)-derived midbrain organoid models deficient for DJ1 activity, we find that lysosomal proteolysis is impaired, causing AGEs to accumulate, -synuclein (-syn) phosphorylation to increase, and proteins to aggregate
G., Licciardi, P
10.1093/infdis/jir658 7
A Phase I dose-escalation trial was conducted in conjunction with chemotherapy for patients with malignant pleural effusion (MPE)
