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doi:10.1016/S0736-4679(98)00011-0

It also reaches the skin cells following the consumption by mouth enhancing skin protection from free radicals produced by exposure to external (UV, blue light, smoke, pollution etc,) and internal factors

Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration (Alavi Naini and Soussi-Yanicostas 2015)

350 Many other studies have also reported ROS inducing potential of DMF, 351,352 suggesting selective anti-inflammatory mechanism of DMF that warrants further investigation