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doi:10.1016/j.apsb.2016.07.014 journal Acta Pharmaceutica Sinica B 2016 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences

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Secreted mainly by dermal papilla cells, IGF-1 promotes hair follicle cell proliferation, vascularization, and transition into the anagen (growth) phase through PI3K/Akt and MAPK/ERK signaling pathways

Nevertheless, the percentage of tumors with a double somatic hit could be underestimated because some tumors also exhibit VUS or uninformative LOH, and the causative effect on the MSI phenotype is uncertain