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General complications include introduction of infection, intravascular injection, anaphylaxis or reaction to the drug injected, and injection of the wrong dose or volume of the drug

The typical hematoxylin and eosin (H&E) staining of major organs including heart, liver, spleen, lung and kidney from mice after different treatments were also observed, which showed excellent biosafety of all these treatments with negligible histomorphological changes (Supplementary Fig

The prevalence of glaucoma is expected to rise to 111.8 million cases by 2040 [1]