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Health 31 , 196214 (2008)

Naltrexone-bupropion (Contrave) Naltrexone-bupropion combines an opioid receptor antagonist with an antidepressant to affect the pleasure-reward areas of the brain and thereby decrease cravings and appetite
However, in some cases the decrease in hemoglobin is so precipitous that blood transfusion is required to save the childs life

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