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B12 levels can decrease with age, as well as being lower in people who have undergone weight loss surgery, or suffer from pernicious anaemia, Crohns or celiac disease

Suntharalingam G, Perry MR, Ward S, Brett SJ, Castello-Cortes A, Brunner MD, et al

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J Orthop Res 24:982989 Liu C, Aschbacher-Smith L, Barthelery N, Dyment N, Butler D, Wylie C (2011) What we should know before using tissue engineering techniques to repair injured tendons: a developmental biology perspective
