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Description
Clinical spectrum of Kufor-Rakeb syndrome in the Chilean kindred with ATP13A2 mutations
As the antecedent show, FRP can exert anti-inflammatory through multiple signaling pathways
Further investigation revealed that the IC50 concentration of CGA, through the depletion of free iron within hepatocytes, significantly reduced the expression of iron-sulfur cluster subunits in mitochondrial complexes I-III and disrupted the oxidative-reductive homeostasis of hepatocytes, ultimately leading to hepatotoxicity
doi: 10.1093/genetics/157.2.875 142 BarrettRDHSchluterD
