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10.1016/j.celrep.2014.12.036

doi: 10.1055/s-2007-1021044

This, in turn, activates immune signaling pathways that amplify the immune response, induce the production of factors with antimicrobial activity, and activate effector pathways

In the mitochondrial-dependent pathway, TcdA and TcdB increase mitochondrial outer membrane permeability (MOMP), releasing cytochrome c and activating caspase 9 [129,133]
