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Additionally, their longer lifespans and ability to spontaneously develop GN with age offer valuable insights into GNs causal mechanisms, surpassing the single-environmental-factor conditions seen in other models

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Further sequencing analysis on the T cells revealed that TE4 mice carried increased activated CD8 + T cells and reduced exhausted T cells, suggesting that the T-cell activation drives tau-mediated neurodegeneration

[DOI] [PubMed] [Google Scholar] 100.Bateman R., Rauh D., Shokat K.M