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Mechanisms of Resistance to Anti-Angiogenic Therapies and Ways to Overcome them Although anti-angiogenesis therapies may prolong progression-free survival (PFS), they have limited impact on overall survival (OS) and do not constitute a permanent cure in RCC, CRC, or breast cancer (73, 75, 82, 83)
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High-intensity physical activity, typical of competitive or extreme sports, is correlated with a high incidence of gastrointestinal disorders and symptoms of increased intestinal permeability
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