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Description
OA is characterized by progressive loss of cartilage extracellular matrix (ECM) and pathological changes in other joint tissues such as subchondral bone sclerosis, osteophyte formation, and synovial inflammation 31
A growing critique posits that such methods may not fully capture instantaneous oxygen consumption from pre-existing stores within the brain tissue itself (the parenchyma) (Schurr, 2025)
In the first step, serotonin becomes acetylated by arylalkylamine N-acetyltransferase (AANAT) to become N-acetyl serotonin, the rate-limiting step
While this seems logical, it rarely works in practice
