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AOD-9604 works through beta-3 receptors, and areas rich in alpha-2 receptors may be relatively resistant to its effects

[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Matsukawa T., Yagi T., Uchida T., Sakai M., Mitsushima M., Naganuma T., Yano H., Inaba Y., Inoue H., Yanagida K., et al

Neuropathology 29:219229 Salvesen L, Ullerup BH, Sunay FB, Brudek T, Lokkegaard A, Agander TK, Winge K, Pakkenberg B (2015) Changes in total cell numbers of the basal ganglia in patients with multiple system atrophya stereological study

What the Research Says While animal studies and cellular research are promising, human trials are sparse
