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The Vitamins: Fundamental Aspects in Health and Nutrition, 4th edn London: Academic Press
[DOI] [PubMed] [Google Scholar] 208.Li S, Gao D, Jiang Y
doi:10.1177/1932296820911919
61,62 One of the major limitations of this study was the low number of patients and the absence of a placebo arm, prompting a placebo-controlled AST-120 Used to Treat Mild Hepatic Encephalopathy (ASTUTE) clinical trial, 63 a multicenter, double-blind RCT that randomized 148 patients with compensated cirrhosis to receive either dose-ranging oral AST-120 (2 or 4 g three times per day) vs
