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The pathways associated with hypoxia and dysregulated immune system have been identified as strong drivers of neurological complications of post-acute sequelae of SARS-CoV-2 infection (evidence from the post-mortem brain studies and observational studies) [97]

Major metabolites found were trimethylamine N-oxide, primarily in urine (8% to 49% of the administered dose) and [3H]--butyrobetaine, primarily in feces (0.44% to 45% of the administered dose)

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Therefore, when designing the carnitine determination experiment, in order to avoid the interference of baseline confounding factors, we must pay special attention to the consistency of age, gender, and renal function between the groups, so that the final determination results are comparable