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Generation of a set of isogenic, gene-edited iPSC lines homozygous for all main APOE variants and an APOE knock-out line

As reported, ROS generates hydrogen peroxide, which is a harmful molecule that can be scavenged by the glutathione peroxidase through GSH, it is found in the cytosol and the mitochondria, and by the catalase which is present in the peroxisomes

Lipoprotein lipase (LPL) hydrolyses TAG present in plasma lipoproteins and supplies NEFA for storage in the adipose tissue, or for oxidation in other tissues, and plays a pivotal role in the regulation of lipid content in fish ( Reference Elliott and Elliott 12 )

It functions as a conditional system capable of relatively rapid responses to a variety of stimuli