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Thus, the capacity of mice carrying an AgRP-specific GHR ablation to save energy during food deprivation is impaired, leading to increased fat loss
A small percentage of mice with only one copy of the GPx-1 allele and complete deficiency of GPx-2 develop mild ileocolitis (GPx-1 +/ GPx-2 / ), whereas a single copy of the GPx-2 gene (GPx-1 / GPx-2 +/ ) protects against inflammation, leading to the suggestion that GPx-2 has a greater protective effect in the intestine than GPx-1 (114), although an earlier study reported that one copy of either of these GPx genes was sufficient to prevent the development of intestinal cancer (72)
Furthermore, the interplay between neuronal energy metabolism and synaptic plasticity is an area of growing interest
