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J., Kundakovic, M., Mitchell, A

The main ongoing studies: REDEFINE 1 , Phase 3 obesity without T2D (results 20242025, preliminarily 25.3 %) REDEFINE 2 , Phase 3 obesity + T2D REDEFINE 3 , Phase 3 cardiovascular outcome trial (n~7000) Stand-alone clinical development of Cagrilintide is limited , Novo Nordisk is primarily investing in the CagriSema combination

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Overall, our molecular data supports BPA as an estrogen agonist that can persistently activate both genomic and nongenomic signaling pathways after developmental exposure