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Supplementation of vitamin B-6 might be warranted for critically ill patients to decrease inflammatory responses and oxidative stress, to increase immune function, and to correct hyperhomocysteinemia during critical illness to prevent subsequent or worsening clinical deterioration

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Possible Repair Mechanisms Cytosolic rat kidney cysteine S -conjugate -lyase (or more accurately GTK) and its mRNA were shown to be elevated in the kidneys of rats given a single nonnephrotoxic dose of N -acetyl- S -(1,2,3,4,4-pentachloro-1,3-butadienyl)-l-cysteine (MacFarlane et al., 1993)

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