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Data Availability Statement The data that support the findings of this study are available in PubMed at These data were derived from the following resources available in the public domain: Purpura et al 2024, Wen et al 2022, Joseph et al 2021, Jacob et al 2021, Gopi et al 2021, Davis et al 2016, Lukawski et al 2020, Mikirova et al 2019, Zmuda et al 2024, McGarry et al 2024,

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Carter BZ, Kornblau SM , Mak PY, Yang H, Qiu Y, Jiang X, Coombes K, Zhang N, Garcia-Manero G, Andreeff M

SOAR and the polybasic STIM1 domains gate and regulate Orai channels