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Ergot alkaloid derivatives, which also stimulate 5-hydroxytryptamine (5-HT) receptors, including the 5-HT2B subtype, were the first dopamine receptor agonists

Here, we propose a framework of the NMDAR as a tripartite signalling receptor complex, that can transduce, compute and transmit information through three parallel streams (i) signalling via the binding of both co-agonists glutamate and glycine to the receptor, (ii) signalling via exclusive glycine binding, and (iii) signalling via exclusive glutamate binding (Fig

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