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Most of these patients showed only partial and transient improvements in metabolic function for several months and finally underwent liver transplantation [121,122,123]

FDA fails to standardize the internal doses associated with the RfC and MRL (and those from amalgam) to body weight due to the great disparity in body weights in the different age groups being considered

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While extrapolated data from UK/US, CF clinics suggest a prevalence of 1:12,0001:40,000 among Indian children (95), a 2020 North Indian study revealed a high CFTR mutation carrier rate of 1:22, signaling a potentially higher prevalence (96)